Cellgevity®: Preventive Potential Against High Fructose Diet-Induced Inflammation And Oxidative Stress

Background: Modern diets high in fructose, have been linked to metabolic disorders, inflammation and oxidative stress. Herbal supplements like Cellgevity®, touted for their anti-inflammatory and antioxidant properties, therefore needed to be investigated. Objectives: This study was aimed to evaluate the potential of Cellgevity®, a herbal supplement, in preventing inflammation and oxidative stress, induced by a high fructose diet. Methods: Twenty male rats, (about 200g each), were divided into four groups of five rats each: the control, high fructose diet with fructose water (HFD+FW), HFD+FW with Atorvastatin (0.57 mg/kg-b.w), and HFD+FW with Cellgevity® (26.15 mg/kg-b.w), groups. After a 28-day experimental period, they were sacrificed and blood samples collected and analyzed for the levels of high sensitive C-reactive protein (HsCRP), malondialdehyde (MDA), and total antioxidant capacity (TAC). Statistical analysis, was done using the SPSS-20 package. Results: Rats on high fructose diet had significantly (P<0.05) elevated HsCRP levels (0.63±0.04 mg/dl) compared to those of the control (0.27±0.01 mg/dl). When compared with the HFD+FW group (0.63±0.04 mg/dl), Atorvastatin and Cellgevity® prevented significantly (P<0.05), the rise in HsCRP levels (0.28±0.00 mg/dl; 0.29±0.01 mg/dl respectively), while only Cellgevity® significantly (P<0.05) prevented an increase in the MDA levels (HFD+FW: 0.32±0.01 μM; Cellgevity®: 0.09±0.02 μM). Atorvastatin and Cellgevity® both significantly (P<0.05) prevented a fall in the TAC levels (0.38±0.03 μmol/ml; 0.59±0.03 μmol/ml respectively) compared to the HFD+FW group (0.21±0.06 μmol/ml), with Cellgevity® being more effective. Conclusion: Cellgevity® therefore showed promise as a supplement that can prevent high fructose diet induced inflammation and oxidative stress.