⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

June 21, 2024Stem Cell Research & TherapyOpen Access

Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes

Hengliang Zhang Payel Sen Jules Hamers Theresa Sittig Brent Woestenburg Alessandra Moretti Andreas Dendorfer Daphne Merkus

View Full Paper

Ask AI

Bookmark

Share

Abstract

Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by traditional methods are a mix of atrial and ventricular CMs and many other non-cardiomyocyte cells. Retinoic acid (RA) plays an important role in regulation of the spatiotemporal development of the embryonic heart.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e63c18b6db6435875ce295 https://doi.org/10.1186/s13287-024-03741-0

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes2024
2Biphasic control of retinoic acid signaling promotes left ventricular-like cardiomyocyte differentiation of human pluripotent stem cellspreclinical · 2026
3Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineagepreclinical · 2022 · 2 citations
4Specific induction of right ventricular-like cardiomyocytes from human pluripotent stem cellsOriginal Research · 2025 · 3 citations
5Electrophysiologic Characterization of Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytespreclinical · 2018 · 58 citations