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June 14, 2024Diabetes

772-P: GLP1RA Use and Risk of Pancreatitis and Biliary Disease in Adults with Type 2 Diabetes and Low to Moderate CV Risk

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Authors

JPJULIE M. PAIKHTHELEN TESFAYESCSara J. Cromer

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Overview

Randomized trial reveals no significant risk of pancreatitis or biliary disease in adults with type 2 diabetes and low CV risk, suggesting treatment safety.

Key Points

  • GLP1RA initiation was not linked to heightened risk for acute pancreatitis or biliary disease.
  • In the GLP1RA group, the hazard ratio for pancreatitis was 1.19 compared to DPP4i and 0.99 against SGLT2i.
  • Assessment using a propensity score-matched analysis involving Medicare and private health plans from 2013 to 2023 led to these findings.2:2:1 ratio of GLP1RA to control groups was employed in the analysis, highlighting potential treatment safety.

Cite This Study

PAIK et al. (2024) studied this question.

synapsesocial.com/papers/68e64c4bb6db6435875dd107https://doi.org/10.2337/db24-772-p
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glucagon-like Peptide-1 Receptor Agonists Are Not Associated with Increased Risk of Acute Pancreatitis or Pancreatic Complications, Including Pancreatic Cancer, in Type 2 Diabetes: A Global Propensity-Matched Cohort Study2026
  2. 2Gastrointestinal and Hepatobiliary Safety of Glucagon-like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes2025 · 10 citations
  3. 3Cohort Study: Risk of Gallstones and Biliary Complications With Glucagon‐Like Peptide‐1 Receptor Agonists in Type 2 Diabetes2026
  4. 4750-P: Association of Glucagon-Like Peptide 1 Receptor Agonists with Incident Parkinson’s Disease in U.S. Older Adults with Type 2 Diabetes2024
  5. 5756-P: Glucagon-Like Peptide-1 Receptor Agonists and the Risk of Endoscopy Failure or Aspiration—A Cohort Study2024