Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 7, 2026United European Gastroenterology Journal

Cohort Study: Risk of Gallstones and Biliary Complications With Glucagon‐Like Peptide‐1 Receptor Agonists in Type 2 Diabetes

View Full Paper
Ask AI
Bookmark
Share

Authors

MEMohamed H. EldesoukiOAOmar AlkasabrahMKMohammed Kloub

Discussion

Loading...

Member takes

Overview

Cohort study shows increased gallbladder disease risk in type 2 diabetes patients using GLP-1 receptor agonists, suggesting caution in treatment.

Key Points

  • This study evaluates the risk of gallbladder disease in patients with type 2 diabetes treated with GLP-1 receptor agonists.
  • Retrospective cohort analysis using the TriNetX research network
  • Inclusion of adults ≥ 18 years with type 2 diabetes receiving GLP-1 RAs compared to matched controls
  • Outcomes assessed include cholelithiasis/choledocholithiasis, cholecystitis, and cholecystectomy.
  • 43,077 patients were in the GLP-1 RA cohort and 113,299 in the control group.
  • At two years, higher rates of cholelithiasis/choledocholithiasis in GLP-1 RA users (aOR 1.44, 95% CI 1.24–1.65).
  • By three years, associations persisted for cholelithiasis (aOR 1.43, 95% CI 1.24–1.63) and cholecystitis (aOR 1.45, 95% CI 1.14–1.83).

Cite This Study

Eldesouki et al. (2026) studied this question.

synapsesocial.com/papers/6a250ac07def13d035e1adcehttps://doi.org/10.1002/ueg2.70238
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gastrointestinal and Hepatobiliary Safety of Glucagon-like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes2025 · 10 citations
  2. 2Glucagon-like Peptide-1 Receptor Agonists Are Not Associated with Increased Risk of Acute Pancreatitis or Pancreatic Complications, Including Pancreatic Cancer, in Type 2 Diabetes: A Global Propensity-Matched Cohort Study2026
  3. 3Glucagon-like peptide 1 receptor agonists: More than just weight loss medications.2026
  4. 4Evaluating the Rates of Pancreatitis and Pancreatic Cancer Among <scp>GLP</scp>‐1 Receptor Agonists: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials2025 · 28 citations
  5. 5772-P: GLP1RA Use and Risk of Pancreatitis and Biliary Disease in Adults with Type 2 Diabetes and Low to Moderate CV Risk2024