Abstract olanzapine is an atypical antipsychotic widely used for the treatment of mania as monotherapy. In this case, it paradoxically caused mania symptoms in a 40-year-old patient with intermittent explosive disorder. This case presents different characteristics from previous reports, suggesting a direct link between olanzapine and mania symptoms. The patient did not have any psychotic or mood disorder, and the symptoms rapidly disappeared during a medication-free period. Furthermore, there was no discontinuation of other medications, no prominent family history of psychiatric disorder, and no addiction to substances, all of which suggest a connection between manic symptoms and olanzapine. Possible receptor and genomic explanations for this phenomenon are also discussed.
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Aghamohammadi et al. (2024) studied this question.
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