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May 21, 2024Open Access

Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

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Authors

AAAdriana K. AlexanderKRKarina F. RodriguezYCYuying Chen

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Overview

Single-nucleus multiomic profiling reveals sexually dimorphic gene regulatory networks in murine primordial germ cells, highlighting chromatin priming mechanisms driving sex determination.

Key Points

  • Regulatory element accessibility precedes gene expression during sex determination, indicating that chromatin changes prime primordial germ cells before differentiation.
  • Divergence between XX and XY lineages increases temporally, with sex-specific transcription factors driving dimorphic gene expression in primordial germ cells.
  • Single-nucleus multiomics profiling of joint RNA and ATAC data captured open chromatin regions alongside transcriptomes across differentiating primordial germ cells.
  • Highlights how chromatin accessibility guides developmental cell fate decisions—murine model; further preclinical work needed to validate signaling interactions.

Cite This Study

Alexander et al. (2024) studied this question.

synapsesocial.com/papers/68e6910cb6db643587618170https://doi.org/10.7554/elife.96591.1
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