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February 21, 2024Open Access

Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

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Authors

AAAdriana K. AlexanderKRKarina F. RodriguezYCYuying Chen

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Overview

Multiomic profiling reveals that chromatin accessibility primes sex-specific gene networks in murine primordial germ cells, highlighting key transcriptional drivers of embryonic sex determination.

Key Points

  • Regulatory chromatin accessibility precedes sexually dimorphic gene expression in murine primordial germ cells, suggesting early epigenomic priming before differentiation begins.
  • Profiling embryonic single-nucleus multiomics revealed distinct transcription factor networks, including female-specific TFAP2c enrichment and male-specific forkhead-box activity.
  • Temporal mapping of WNT and BMP signaling illuminates mammalian germ cell programming—murine model; further preclinical work needed to validate human sex determination pathways.

Cite This Study

Alexander et al. (2024) studied this question.

synapsesocial.com/papers/68e7845cb6db6435876f72e5https://doi.org/10.1101/2024.02.19.581036
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