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October 7, 2025Canadian Journal of Neurological Sciences / Journal Canadien des Sciences NeurologiquesOpen Access

Reviewer Comment on Almekhlafi et al. “Adjunctive Intraarterial Thrombolysis after Thrombectomy in Large Vessel Occlusion Stroke: A Meta-Analysis of RCTs”

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Key Points

Intraarterial thrombolysis appears to enhance outcomes after thrombectomy in large vessel occlusion strokes, potentially reducing complications.
Analysis of randomized control trials indicates that adjunctive treatments may improve patient recovery and long-term outcomes.
Meta-analysis method aggregated data from multiple studies, helping to identify significant trends and efficacy in treatment options.
This finding may encourage further research to establish definitive guidelines and treatment protocols for stroke management.

Implication

Meta-analysis of RCTs highlights intraarterial thrombolysis in stroke patients, suggesting potential benefits.

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Cite This Study

Beom Joon Kim (2025) studied this question.

synapsesocial.com/papers/68e6a0f4718ef0a556b33d4a https://doi.org/10.1017/cjn.2025.10355

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic StrokeOriginal Research · 2026
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3Response to Letter Regarding Article, “Adjunctive Thrombectomy for Acute Myocardial Infarction: A Bayesian Meta-Analysis”editorial · 2010 · 1 citations
4ABSTRACT NUMBER: ESOC2026A153 EFFICACY AND SAFETY OF ADJUNCTIVE INTRA-ARTERIAL THROMBOLYSIS FOLLOWING ENDOVASCULAR THROMBECTOMY IN ACUTE ISCHEMIC STROKE: AN UPDATED META-ANALYSIS OF RANDOMISED CONTROLLED TRIALSMeta-Analysis · 2026 · 1 citations
5ABSTRACT NUMBER: ESOC2026A1189 ADJUNCTIVE INTRA-ARTERIAL ALTEPLASE AFTER NEAR-COMPLETE OR COMPLETE REPERFUSION IN ACUTE ISCHEMIC STROKE: A POST HOC ANALYSIS OF THE PEARL TRIALRCT · 2026