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May 15, 2024Open Access

Figure 4 from FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA

Ann‐Marie Baker Gayathri Nageswaran Pablo Nenclares Tahel Ronel Kane Smith Christopher Kimberley Miangela M. Laclé Shreerang Bhide Kevin J. Harrington Alan Melcher Manuel Rodriguez‐Justo Benny Chain Trevor A. Graham

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Abstract

A, Hematoxylin and eosin showing the regions of FFPE adenoma and carcinoma that were macrodissected for RNA extraction and FUME-TCRseq. Scale bar, 5 mm. B, Bar chart showing the numbers of unique TCR clonotypes detected in carcinoma and adenoma regions. C, Bar chart showing the diversity of the TCR repertoire in carcinoma and adenoma regions. D, Plot showing the frequencies of the 10 most common clonotypes detected in the adenoma region and the frequencies at which they appear in the carcinoma.

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Baker et al. (2024) studied this question.

synapsesocial.com/papers/68e6a13db6db643587624e07 https://doi.org/10.1158/0008-5472.25826420.v1

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure 6 from FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA2024
2Figure 5 from FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA2024
3Data from FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA2024
4Figure 2 from FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA2024
5FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA2024 · 5 citations

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Supplementary Data from FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA2024
Supplementary Data from FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA2024
Figure 3 from FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA2024