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The article provides a review of literature data on the principles of creating multi-targeted drugs and their mechanisms of action, and analyses the results of studying the antimicrobial activity of quinazolinone derivatives that exhibit multi-targeted effects against bacteria of the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter). The search for substances that can affect several targets in a bacterial cell will be a way to solve the problem of pathogen resistance to antimicrobial agents used in modern medical practice.
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Старикова et al. (2024) studied this question.
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