Analysis of gene expression differences pre- and post-lytic reactivation of Epstein–Barr virus in Burkitt's lymphoma

Aim: This study explores changes in viral and host gene expressions during Epstein–Barr virus lytic reactivation, establishing a bioinformatics foundation for understanding the pathogenesis of Burkitt's lymphoma (BL) and identifying potential therapeutic targets. Methods: We used the data set GSE141220 to assess differentially expressed genes. Subsequent analyses included Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment. Hub genes were identified using Cytoscape. Results: Viral gene expression exhibited significant alterations 24 h after treatment with Sodium butyrate (NaB). Upregulated host genes mainly related to the PI3K-Akt and MAPK signaling pathways. Conclusion: Epstein–Barr virus lytic reactivation is likely to involve the activation of the PI3K-Akt and MAPK signaling pathways. Hub genes may serve as therapeutic targets for BL.