Abstract 1108: Sex And Racial Differences In The Outcomes Of Intravascular Ultrasound-guided Percutaneous Coronary Intervention: A Five-year Retrospective Analysis

Introduction: Studies have shown the superiority of intravascular ultrasound-guided percutaneous coronary intervention (IVUS-PCI) over angiographic PCI alone. We studied the racial and sex differences in outcomes. Methods: Using the National Inpatient Sample database (2016-2020) and ICD-10 codes, we identified the IVUS-PCI population. Chi-square and student T-tests were used to compare categorical and mean differences. Multivariate logistic regression analysis was used to account for potential confounding variables such as sex, age, comorbidities, hospital size, and teaching status and to estimate the probability of outcomes. Our primary outcome was mortality. A p≤0.05 was significant. Results: Of the 271,530 PCI hospitalizations, 12% (32,675) got IVUS-PCI (63.7 years ± 11.7), of which 30.4% (9,925) were females. The probability of receiving IVUS-PCI was similar among all races: 1.04 (0.9-1.1, p=0.7) and sex 1.01 (0.9-1.03, p=0.6). Compared to Whites, Blacks 0.8 (0.6-1.2), Hispanics 0.9 (0.7-1.4), and Asians 1.3 (0.8-2.2), (p>0.05, each) did not differ in mortality. Also, no sex differences in mortality, with females 1.2 (1.0-1.5, p>0.05). Post-procedural shock 2.5 (1.5-4.0), bleeding 1.8 (1.3-2.6), and anemia 1.5 (1.3-1.8) (p<0.05, each) were more likely in females. No racial differences were noted. Conclusion: In our IVUS-PCI population, there was no difference in mortality among race or sex. However, females were more likely to suffer peri and post-procedural complications. More research is needed to identify the drivers of these disparities.