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January 27, 2014Journal of the American Heart AssociationOpen Access

Sex‐Based Differences in Outcomes After Percutaneous Coronary Intervention for Acute Myocardial Infarction: A Report From TRANSLATE‐ACS

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Why the study?

Does female sex affect the 1-year risk of major adverse cardiac events and bleeding in acute myocardial infarction patients undergoing PCI compared to male sex?

Population

6,218 acute myocardial infarction patients undergoing percutaneous coronary intervention at 210 US…

Comparison

Female sex vs Male sex

Design

Cohort

Follow-up

1-year

Authors

CHConnie N. HessLMLisa A. McCoyHDHesha J. Duggirala

Discussion

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Overview

Women post-AMI PCI retain higher adjusted bleeding risk without excess MACE; leaves open whether sex-specific mitigation improves net outcomes.

Structured PICO

Does female sex affect the 1-year risk of major adverse cardiac events and bleeding in acute myocardial infarction patients undergoing PCI compared to male sex?

P
Population
6,218 acute myocardial infarction patients undergoing percutaneous coronary intervention (PCI) at 210 US hospitals, 27.5% female.
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
1-year risk of major adverse cardiac events and bleeding according to Global Utilization of Strategies To Open Occluded Arteries (GUSTO) and Bleeding Academic Research Consortium (BARC) definitionscomposite

In patients undergoing PCI for acute MI, women have a higher risk of bleeding compared to men that is not explained by baseline characteristics, whereas their higher unadjusted MACE rate is driven by baseline clinical differences.

Cite This Study

Hess et al. (2014) studied this question.

synapsesocial.com/papers/6a1d137e73c56dd1bd2f1d90https://doi.org/10.1161/jaha.113.000523
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Also Consider

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