Key result
In STEMI patients undergoing PCI, female sex was not an independent predictor of 2-year mortality (HR 1.33; P=0.55) but independently predicted major bleeding (HR 3.53; P=0.017).
Why the study?
Does female sex independently predict 2-year mortality and bleeding in patients undergoing PCI for various clinical presentations of coronary artery disease?
Cohort (n=10,724)
No
Does female sex independently predict 2-year mortality and bleeding in patients undergoing PCI for various clinical presentations of coronary artery disease?
Hazard Ratio: 1.33 (95% CI 0.52–3.38)
Absolute Event Rate: 6.7% vs 1.4%
p-value: p=0.55
In patients undergoing PCI for STEMI, the higher observed 2-year mortality in women is explained by baseline characteristics, but women remain at independently higher risk for major bleeding.
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Mortality risk equalized after adjustment in women with STEMI PCI, yet bleeding risk remains elevated; hypothesis-generating for tailored antithrombotic regimens.
Tang et al. (2017) conducted a cohort in Coronary artery disease undergoing percutaneous coronary intervention (n=10,724). Female sex vs. Male sex was evaluated on All-cause death in STEMI patients (HR 1.33, 95% CI 0.52-3.38, p=0.55). In STEMI patients undergoing PCI, female sex was not an independent predictor of 2-year mortality (HR 1.33; P=0.55) but independently predicted major bleeding (HR 3.53; P=0.017).
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