Key result
Female sex in STEMI is linked to ~81% higher major bleeding risk post-PCI despite similar MACE.
Why the study?
Does female sex independently predict increased risk of bleeding and major adverse cardiac events (MACE) in patients with STEMI undergoing primary PCI?
Does female sex independently predict increased risk of bleeding and major adverse cardiac events (MACE) in patients with STEMI undergoing primary PCI?
In patients with STEMI, female sex is an independent predictor of long-term major bleeding but not of MACE, as the higher unadjusted MACE rates in women are driven by baseline comorbidities.
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May support enhanced bleeding monitoring in women post-STEMI PCI; leaves open targeted strategies in adjusted cohorts.
Yu et al. (2014) studied this question. Women with STEMI had a 81% higher risk of major bleeding (HR 1.81) compared to men at 3 years post-percutaneous coronary intervention, despite not showing increased MACE risk.
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