A mild and efficient protocol for visible-light-photocatalyzed C5 nitration of 8-aminoquinoline derivatives was developed utilizing Cu(NO3)2∙3H2O as a nitro source. The reaction proceeded smoothly under very mild conditions, employing Acid Red 94 and a commercial household light bulb as an organic photosensitizer and a light source, respectively, making this synthetic procedure green and easy to operate. Furthermore, most products could be obtained through recrystallization, which enhanced the operational simplicity of this method.
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Liu et al. (2024) studied this question.
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