Pd61-08 Impact of Preoperative Luts on Health-Related Quality of Life Following Radical Prostatectomy—a Propensity Score Matched Longitudinal Study

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy IV (PD61)1 May 2024PD61-08 IMPACT OF PREOPERATIVE LUTS ON HEALTH-RELATED QUALITY OF LIFE FOLLOWING RADICAL PROSTATECTOMY—A PROPENSITY SCORE MATCHED LONGITUDINAL STUDY Thilo Westhofen, Enya Feyerabend, Alexander Buchner, Severin Rodler, Lennert Eismann, Friedrich Jokisch, Armin Becker, Christian G. Stief, and Alexander Kretschmer Thilo WesthofenThilo Westhofen , Enya FeyerabendEnya Feyerabend , Alexander BuchnerAlexander Buchner , Severin RodlerSeverin Rodler , Lennert EismannLennert Eismann , Friedrich JokischFriedrich Jokisch , Armin BeckerArmin Becker , Christian G. StiefChristian G. Stief , and Alexander KretschmerAlexander Kretschmer View All Author Informationhttps://doi.org/10.1097/01.JU.0001009352.31737.3d.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Evidence on the impact of preoperative lower urinary tract symptoms (LUTS) on outcome after radical prostatectomy (RP) is controversial particularly with regards to the impact on long-term health related Quality of life (HRQOL). We therefore aimed to assess the impact of preoperative LUTS on long-term HRQOL up to 10 years after RP for prostate cancer (PC). METHODS: Within our prospective institutional database of 6487 patients treated with RP for PC (2008– 2020), 2727 patients with preoperative LUTS (IPSS score of≥8) were identified. A 1:1 propensity-score matched analysis of 3056 men (n=1528 LUTS, n=1528 no LUTS) was conducted. Primary endpoint was HRQOL (based on EORTC QLQ-C30 and PR25). Linear regression models tested the effect of preoperative LUTS on the net change in general HRQOL (p<0.05). RESULTS: Median follow-up was 48 months. Preoperative mean GHS score (67.4 vs. 75.7) was significantly lower in the LUTS cohort (p<0.001). Post-RP the difference in general HRQOL between the LUTS cohort and the no-LUTS cohort became smaller (65.7 vs. 67.8), however remaining statistically significant (p=0.037). In long-term follow-up, general HRQOL was comparable between both subcohorts (p-range 0.716 - 0.876) (Figure 1). Multivariable linear regression analysis revealed increased preoperative IPSS as an independent predictor for increased perioperative improvement of IPSS (p<0.001) CONCLUSIONS: For patients undergoing RP, preoperative LUTS were associated with a postoperative improvement of HRQOL outcomes. In long-term follow-up HRQOL was comparable to patients without preoperative LUTS. Hence RP is an efficient option to treat PC as well as LUTS in those patients. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1282 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Thilo Westhofen More articles by this author Enya Feyerabend More articles by this author Alexander Buchner More articles by this author Severin Rodler More articles by this author Lennert Eismann More articles by this author Friedrich Jokisch More articles by this author Armin Becker More articles by this author Christian G. Stief More articles by this author Alexander Kretschmer More articles by this author Expand All Advertisement PDF downloadLoading ...