Supplementary Figure S9 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

Sarah B. Gitto; Margaret Whicker; Gareth Davies; Sushil Kumar; Krista Kinneer; Haineng Xu; Arthur Lewis; Srinivas Mamidi; Sergey Medvedev; Hyoung Kim; Judith Anderton; E. Jessica Tang; Benjamin Ferman; Steven Coats; Robert W. Wilkinson; Eric J. Brown; Daniel J. Powell; Fiona Simpkins

doi:10.1158/1078-0432.25603617.v1

April 15, 2024Open Access

Supplementary Figure S9 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

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Key Points

B7-H4-targeting antibody-drug conjugates demonstrate antitumor activity across platinum-resistant models, halting tumor progression in mice.
Individual animal measurements and statistical analysis from WO-2 patient-derived xenograft experiments confirm significant tumor suppression in vivo.
Evaluation in patient-derived xenograft mouse models underscores therapeutic potential against drug-resistant tumors; mouse model limits translation.

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Implication

In vivo study demonstrates antitumor activity of a B7-H4-targeting antibody-drug conjugate in resistant cancer models, highlighting potential therapeutic efficacy.

Abstract

Individual mouse data and statistical analysis of WO-2 PDX in vivo study.

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Gitto et al. (2024) studied this question.

synapsesocial.com/papers/68e6f2a2b6db64358766d0c2 https://doi.org/10.1158/1078-0432.25603617.v1

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Supplementary Figure S9 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S9 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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