Supplementary Figure S11 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

Sarah B. Gitto; Margaret Whicker; Gareth Davies; Sushil Kumar; Krista Kinneer; Haineng Xu; Arthur Lewis; Srinivas Mamidi; Sergey Medvedev; Hyoung Kim; Judith Anderton; E. Jessica Tang; Benjamin Ferman; Steven Coats; Robert W. Wilkinson; Eric J. Brown; Daniel J. Powell; Fiona Simpkins

doi:10.1158/1078-0432.25603644.v1

April 15, 2024Open Access

Supplementary Figure S11 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

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Key Points

Treatment with a B7-H4-targeting antibody-drug conjugate demonstrates antitumor activity across resistant tumor models with confirmed expression of the target protein.
In vivo study evaluations of individual mice in the WO-19 patient-derived xenograft model provide detailed statistical analysis of tumor responses and drug efficacy.
Supports the therapeutic targeting of B7-H4 in tumors resistant to PARP inhibitors and platinum-based therapies; preclinical mouse model requires further validation.

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Implication

Animal study demonstrates antitumor activity of a B7-H4-targeting antibody-drug conjugate in drug-resistant cancers, highlighting therapeutic potential in refractory tumors.

Abstract

Individual mouse data and statistical analysis of WO-19 PDX in vivo study.

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Gitto et al. (2024) studied this question.

synapsesocial.com/papers/68e6f2a2b6db64358766d0e0 https://doi.org/10.1158/1078-0432.25603644.v1

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Supplementary Figure S11 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S11 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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