Nitrous Oxide is a potent analgesic. It is known commonly as "laughing gas" due to feelings of euphoria experienced on inhalation with a rapid onset of action and short duration, which has made it an increasingly popular recreational drug. Routine drug screens do not test for this, so patient history is crucial in the assessment of exposure. Nitrous oxide toxicity can mimic neuropathy but is reversible with high levels of vitamin B12 supplementation when identified early.
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Munir et al. (2024) studied this question.
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