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April 8, 2024Open Access

Multivalent S2-subunit Vaccines Provide Broad Protection Against Clade 1 Sarbecoviruses

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Authors

RKRavi S. KaneGeorgia Institute of TechnologyPHPeter HalfmannUniversity of North Carolina at Chapel HillRPRajiv M. PatelAmity University

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Implication

Preclinical challenge study demonstrates broad protection against sarbecoviruses in transgenic mice, highlighting conserved S2 subunits as viable vaccine targets.

Key Points

  • Nanoparticle vaccines displaying SARS-CoV-1 S2 subunits provide broad protection against Omicron subvariant XBB and emergent clade 1 sarbecoviruses.
  • Challenge studies in transgenic K18-hACE2 and Fc-gamma receptor knockout mice demonstrate broad protection against bat and pangolin sarbecoviruses.
  • Findings highlight antibody-based cellular effector mechanisms as critical for broad immunity; mouse model necessitates further preclinical testing.

Cite This Study

Kane et al. (2024) studied this question.

synapsesocial.com/papers/68e700e1b6db64358767ad65https://doi.org/10.21203/rs.3.rs-4177301/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine2024 · 34 citations
  2. 2A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein2022 · 81 citations
  3. 3Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron2023 · 49 citations
  4. 4Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors2021 · 237 citations
  5. 5Multivalent S2-based vaccines provide broad protection against SARS-CoV-2 variants of concern and pangolin coronaviruses2022 · 67 citations