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February 12, 2024Nature CommunicationsOpen Access

Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine

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PHPeter HalfmannKLKathryn LoefflerADAugustine Duffy

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Halfmann et al. (2024) studied this question.

synapsesocial.com/papers/68e796dbb6db643587707b8ehttps://doi.org/10.1038/s41467-024-45495-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multivalent S2-subunit Vaccines Provide Broad Protection Against Clade 1 Sarbecoviruses2024
  2. 2Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice2025 · 21 citations
  3. 3Characterization and immunogenicity of nanoparticle vaccines based on Clade 2 and Clade 3 sarbecovirus S2 proteins2025
  4. 4Development of a Thermostable and Broadly Neutralizing Pan-Sarbecovirus Vaccine Candidate2025
  5. 5SARS-CoV-2 vaccination and infection elicit cross-neutralizing responses against clade 3 and 4 sarbecoviruses2026