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December 12, 2025npj VaccinesOpen Access

Characterization and immunogenicity of nanoparticle vaccines based on Clade 2 and Clade 3 sarbecovirus S2 proteins

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Authors

PHPeter HalfmannRPRaj S. PatelADAugustine Duffy

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Overview

Characterization reveals S2-based vaccines induce cross-reactive antibodies in mice, suggesting protective potential against diverse sarbecoviruses.

Key Points

  • To evaluate the immunogenicity of nanoparticle vaccines derived from clade 2 and clade 3 sarbecovirus S2 proteins.
  • Developed multivalent subunit vaccines using S2 proteins from clade 2 and clade 3 sarbecoviruses.
  • Evaluated the immunogenic response in female mice by assessing antibody production against multiple clades of sarbecoviruses.
  • Vaccines induced cross-reactive antibodies capable of binding to clade 1, 2, and 3 sarbecovirus antigens.
  • Female mice showed protection against challenges from clades 1a and 1b, including SARS-CoV-2 strain XBB.

Cite This Study

Halfmann et al. (2025) studied this question.

synapsesocial.com/papers/6940190c2d562116f28f646ahttps://doi.org/10.1038/s41541-025-01333-4
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