Abstract PL03-02: From microniches to single cells: Understanding the impact of intratumoral microbes on spatial and cellular heterogeneity in cancer

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Tumor heterogeneity is influenced by the presence and localization of intratumoral microbiota within cancer tissues.
The study highlights specific bacteria like Fusobacterium and Treponema that interact with human immune cells and epithelial cells.
Utilizing spatial transcriptomics and single-cell RNA sequencing, researchers analyzed interactions between microbiota and tumor cells in patient specimens and identified distinct microbial niches in tumors. ERCPOU_6-23 involves upregulating MAPKs and immune checkpoint proteins, influencing cancer progression and T-cell levels.

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New insights reveal how intratumoral microbes affect tumor heterogeneity, suggesting potential therapeutic targets.

Susan Bullman (2024) studied this question.

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