April 5, 2024Cancer Research

Abstract LB223: The molecular landscape of injury-induced mammary epithelial cell fate switching

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Authors

QMQueralt Vallmajó Martín NLNikki K. LytleMedical College of Wisconsin DMDivya MuraliUniversity of California, San Diego

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Implication

Preclinical study reveals injury-induced cell state reprogramming toward embryonic progenitor states in mammary basal cells, highlighting actionable mechanisms to curb breast tumor heterogeneity.

Key Points

Mammary basal cells rapidly adopt a developmentally unstable hybrid cell state resembling embryonic progenitors upon transplantation into injured tissue environments.
CRISPR-mediated homologous recombination in mice distinguished basal and luminal lineages in real time, revealing Sox11 expression during cell state reprogramming.
Findings highlight cellular plasticity as an early breast cancer driver and actionable therapeutic target; murine and xenograft models require clinical validation.

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Martín et al. (2024) studied this question.

synapsesocial.com/papers/68e70461b6db64358767e989 https://doi.org/10.1158/1538-7445.am2024-lb223

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Implication

Preclinical study reveals injury-induced cell state reprogramming toward embryonic progenitor states in mammary basal cells, highlighting actionable mechanisms to curb breast tumor heterogeneity.

Abstract LB223: The molecular landscape of injury-induced mammary epithelial cell fate switching

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract LB223: The molecular landscape of injury-induced mammary epithelial cell fate switching

Discussion

Member takes

Implication

Key Points

Cite This Study

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