What question did this study set out to answer?

To characterize the heterogeneity of PROCR+ mammary epithelial cells and their link to breast cancer.

Single Cell Multiomic Profiling of PROCR+ Cells in Mouse Mammary Gland and Breast Cancer...

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Single cell profiling reveals heterogeneity in epithelial cells, indicating a link to aggressive breast cancer subtypes.

To characterize the heterogeneity of PROCR+ mammary epithelial cells and their link to breast cancer.
Utilized targeted FACS enrichment to isolate PROCR+ cells.
Employed single-cell RNA sequencing to profile gene expression.
Performed chromatin accessibility profiling to investigate regulatory elements.
Analyzed multiple developmental stages of mammary epithelial cells.
Identified a novel PROCR+, Cdh5-, Col1a1+ population with high developmental potential.
Revealed transcriptional regulatory mechanisms influencing stem cell identity.
Found expression patterns correlating with aggressive breast cancer subtypes like triple-negative.

Silva et al. (2026) studied this question.

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