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p15E-3C mimotope-induced inhibition of MC38 tumor growth is CD8⁺ T-cell dependent. Mice received 2 µg p15E-3C liposomal vaccine on days 0 and 7 before challenge with 1 × 10⁶ MC-38 cells on day 14 (n = 6). A, Schedule of injections and tumor inoculation. Mice received 400 µg CD8 MAb or CD4 MAb on day 12 and day 13 as indicated; 200 µg CD8 mAb or CD4 mAb on day 18 and day 22 as indicated. B, Average tumor volume of indicated groups. C, Percentage of mice with tumor length shorter than 10 mm. D, Tumor volumes of individual mice from indicated groups. Datapoints represent mean values of 6 mice from the same group for B. Error bars show mean − SD.
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Zhou et al. (2024) studied this question.
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