FIGURE 7 from Identification of Enhanced Vaccine Mimotopes for the p15E Murine Cancer Antigen

p15E e-mimotope vaccines inhibit tumor growth after immunization. A, Schedule of vaccination and tumor inoculation for MC38 therapeutic challenge. Mice were inoculated with 1 × 10⁵ MC38 cells subcutaneously followed with immunization with 2 µg peptide loaded liposomal vaccine on days 2 and 9. Tumor volume (B) and the percentage of mice with a tumor diameter <10 mm (C). Tumor volume of individual mice from the control group (D), wild-type group (E), 3M group (F), 3C group (G), and 3C2V group (H). I, Schedule of vaccination and tumor inoculation for B16-F10 prophylactic challenge. J, Tumor volume of all mice. K, Tumor volume on day 13 after tumor inoculation. L, The percentage of mice with a tumor diameter < 10 mm. Datapoints represent mean values of 5 mice from the same group for B and J or individual values of 5 mice from the same group in K. Statistical analysis of K applied one-way ANOVA followed by Tukey multiple comparisons tests. Statistical analysis of C and L applied log-rank (Mantel–Cox) test. * and ** indicating P < 0.05 and 0.01, respectively. Error bars show mean + or ± SD.