April 1, 2024Open Access

IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

CZChenlei ZhengXi'an University of Architecture and Technology JWJunli WangDalian Medical University YZYu ZhouZunyi Medical University

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) features an immunosuppressive tumor microenvironment (TME) that resists immunotherapy. Tumor-associated macrophages, abundant in the TME, modulate T cell responses. Bone marrow stromal antigen 2-positive (BST2

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Zheng et al. (Mon,) studied this question.

synapsesocial.com/papers/68e70d8cb6db64358768704a https://doi.org/https://doi.org/10.1016/j.celrep.2024.114088

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