Lactated Ringer’s or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension

Jayshil J. Patel; Jamie Jasti; Kurt Hu

doi:10.1097/ccm.0000000000006764

October 1, 2025Critical Care Medicine

Lactated Ringer’s or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension

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Key Points

Normal saline and lactated Ringer’s are compared for initial fluid resuscitation effectiveness in sepsis-induced hypotension, revealing significant clinical implications.
The study highlights initial fluid resuscitation with either lactated Ringer’s or normal saline, suggesting a need for clearer guidelines in managing sepsis-induced hypotension.
In a clinical trial assessing fluid types, findings suggest that lactated Ringer’s may offer advantages in critical care settings over normal saline for sepsis management.
This comparison underscores the importance of fluid choice in sepsis management, supporting ongoing efforts to establish best practices in critical care protocols.

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Implication

Comparative analysis assesses fluid resuscitation options for hypotension in sepsis, suggesting optimal choice. This research highlights the clinical implications of fluid type in treatment effectiveness.

Abstract

1 Division of Pulmonary & Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI. 2 Resuscitation Research Center, Co-Director—Clinical and Translational Research Concentration, Medical College of Wisconsin, Milwaukee, WI. 3 Division of Pulmonary & Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI. Dr. Jasti received support for article research from the National Institutes of Health. Dr. Hu received funding from Sanofi/Regeneron, AstraZeneca, Pulmonx, and Verona. Dr. Patel has disclosed that he does not have any potential conflicts of interest.

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Patel et al. (2025) studied this question.

synapsesocial.com/papers/68e70dab90569dd607ee5f6d https://doi.org/10.1097/ccm.0000000000006764

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Lactated Ringer’s or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension

Key Points

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Implication

Abstract

Discussion

Cite This Study

Lactated Ringer’s or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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