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October 9, 2025Acta OncologicaOpen Access

Up-regulation of intra-tumour LDLR gene expression is associated with statin treatment and better prostate cancer prognosis

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Authors

KFKia Eistrup FonfaraJFJacob FredsøeBUBenedicte P. Ulhøi

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Overview

Observational analysis revealed increased LDLR expression in prostate cancer patients on statins, suggesting improved outcomes.

Key Points

  • Higher intra-tumour LDLR expression in prostate cancer patients was linked to statin use, indicating better prognosis.
  • Gene Set Enrichment Analysis showed 163 differentially expressed genes in prostate cancer samples, highlighting altered pathways.
  • The study utilized whole-transcriptome profiling from 186 radical prostatectomy specimens to assess gene expression patterns.
  • These findings support the potential benefits of statins in prostate cancer treatment through LDLR upregulation.

Cite This Study

Fonfara et al. (2025) studied this question.

synapsesocial.com/papers/68e70db290569dd607ee61bbhttps://doi.org/10.2340/1651-226x.2025.43788
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins2016 · 64 citations
  2. 2Characteristics, clinical significance, and cancer immune interactions of lipid metabolism in prostate cancer2024 · 1 citations
  3. 3Lipid reprogramming as driver of statin-targetable vulnerability in early-onset prostate cancer.2026
  4. 4Prognostic Role of Preoperative Serum Lipid Levels in Patients Undergoing Radical Prostatectomy for Clinically Localized Prostate Cancer2017 · 49 citations
  5. 5Tumor Cholesterol Synthesis, Statin Use, and Lethal Prostate Cancer.2025