What type of study is this?

October 9, 2025Journal of Veterinary Pharmacology and Therapeutics

Pharmacokinetics of Remimazolam Versus Midazolam After Intravenous Administration to Horses

View Full Paper

Ask AI

Bookmark

Authors

MKMiwako KawashimaNihon University TKTaisuke KurodaJapan Racing Association YMYohei MinamijimaLaboratory of Racing Chemistry

Discussion

Member takes

Implication

Randomized crossover trial compared pharmacokinetics and sedative effects of remimazolam and midazolam in Thoroughbred horses, indicating RMZ may offer faster recovery.

Key Points

Remimazolam demonstrated a significantly shorter half-life compared to midazolam, with 0.77 hours versus 3.7 hours.
Plasma clearance for remimazolam was measured at 14.0 L/kg/h, significantly higher than midazolam's 0.45 L/kg/h.
The study involved six Thoroughbred horses receiving a single intravenous dose of either remimazolam or midazolam.
Muscle relaxation and ataxia were observed shortly after remimazolam administration, indicating quick sedative effects.

Cite This Study

Kawashima et al. (2025) studied this question.

synapsesocial.com/papers/68e70db290569dd607ee61e6 https://doi.org/10.1111/jvp.70030

View Full Paper

Ask AI

Bookmark

Implication

Randomized crossover trial compared pharmacokinetics and sedative effects of remimazolam and midazolam in Thoroughbred horses, indicating RMZ may offer faster recovery.

Pharmacokinetics of Remimazolam Versus Midazolam After Intravenous Administration to Horses

Discussion

Member takes

Implication

Key Points

Cite This Study

Pharmacokinetics of Remimazolam Versus Midazolam After Intravenous Administration to Horses

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider