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In renal transplantation, different mechanisms are sought to improve the renal function of the graft. Preclinical studies have identified the upregulation of NAD+ as a potential strategy for the prevention and treatment of AKI (Acute kidney injury). NAD+ is the final metabolized form of vitamin B3. A recent clinical study found that COVID-19 related AKI was associated with NAD+ biosynthetic impairment arising in the context of ischemic, inflammatory, or toxic kidney injury.
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RIVAS et al. (2024) studied this question.
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