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March 25, 2024Open Access

Endothelial natriuretic peptide receptor-C: all clear?

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Authors

FWF. WernerTPTamara PotapenkoKVKatharina Völker

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Overview

Mouse study demonstrates that deleting endothelial NPR-C blunts age-related cardiac hypertrophy and preserves ventricular function, suggesting therapeutic potential for heart failure.

Key Points

  • Deletion of endothelial natriuretic peptide receptor-C blunts aging-related cardiomyocyte hypertrophy and preserves ventricular function by reducing peptide clearance.
  • Knockout mice showed sustained ANP and CNP plasma levels alongside elevated cardiac cGMP and activated PKGI pathways, without altering blood pressure or collagen content.
  • Assessment in endothelial knockout mice demonstrates that inhibiting clearance enhances protective peptide signaling; mouse model results require further preclinical validation.

Cite This Study

Werner et al. (2024) studied this question.

synapsesocial.com/papers/68e7286db6db6435876a2b34https://doi.org/10.14293/cgmp.24000063.v1
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Also Consider

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  4. 4Role of natriuretic peptide receptor C signalling in obesity‐induced heart failure with preserved ejection fraction with pulmonary hypertension2020 · 2 citations
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