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March 15, 2024PLoS ONEOpen Access

Investigating animal reservoirs for hepatitis E virus in Bangui, Central African Republic

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Authors

MNMarina Prisca de Marguerite Nombot-YazenguetAMAbdou Fatawou ModiyinjiVTVianney Tricou

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Overview

Prospective study reveals hepatitis E virus subtype 3h infection in farmed pigs but not goats, highlighting swine as an animal reservoir linked to human disease.

Key Points

  • Farmed pigs harbor hepatitis e virus genotype 3 strains closely related to human infections, whereas local goats show no detectable viral presence across sampled city districts.
  • A total of 36.1% of domestic pigs tested positive for hev rna, and nested-pcr sequencing successfully amplified 12 of these positive specimens for genomic classification.
  • Prospective screening with real-time rt-pcr and phylogenetic analysis reveals subtype 3h in swine, highlighting domestic pigs as an animal reservoir requiring sustained monitoring.

Cite This Study

Nombot-Yazenguet et al. (2024) studied this question.

synapsesocial.com/papers/68e73dc3b6db6435876b6ce9https://doi.org/10.1371/journal.pone.0300608
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