The article highlights the pharmacological activity of berberine, as well as its place in the treatment of the current epidemic - metabolic syndrome. The review examines the molecular mechanisms that allows achieving anti-inflammatory, antimicrobial and antioxidant effects in detail. Berberine’s pharmacological profile makes it possible to have a positive effect on the pathway of obesity, non-alcoholic fatty liver disease, dyslipoproteinemia, the intestinal microbiome and insulin resistance. In addition, the article reviews the main pharmacokinetic parameters and side effects of chemically unmodified berberine.
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Shrayner et al. (2024) studied this question.
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