An iron-catalyzed lactonization reaction via intramolecular C(sp3)-H functionalization is described. The process employs easily accessible hydroxamate derivatives from which the noncommon insertion of the oxygen occurred through a 1,5-hydrogen atom transfer. A mixture of water and hexafluoroisopropanol as solvent appeared to be the key parameter of this transformation to reach a high selectivity and efficiency.
No takes yet. Share an insight, caveat, or question.
Esteves et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: