March 1, 2024HLA

Detection of the HLA‐B*40:01:35 allele in a Taiwanese individual

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Nucleotide substitutions in codons −1 and 84 of the HLA-B*40:01:01 sequence generate the novel allele designated as HLA-B*40:01:35 in Taiwan.
The novel allele differs at 2 codon positions, separating HLA-B*40:01:35 from the reference HLA-B*40:01:01 sequence within this individual.
Identification of HLA-B*40:01:35 highlights ongoing human leukocyte antigen diversification, expanding known alleles for transplantation matching.

Implication

Genetic analysis reveals the novel HLA-B*40:01:35 allele in a Taiwanese individual, indicating further diversity in human leukocyte antigens.

Nucleotide substitutions in codons −1 and 84 of HLA‐B*40:01:01 result in a novel allele, HLA‐B*40:01:35.

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Yang et al. (2024) studied this question.

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Genetic analysis reveals the novel HLA-B*40:01:35 allele in a Taiwanese individual, indicating further diversity in human leukocyte antigens.

Nucleotide substitutions in codons −1 and 84 of HLA‐B*40:01:01 result in a novel allele, HLA‐B*40:01:35.