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The aim is to identify and characterize a novel allele of the HLA-B gene in a specific individual.

March 12, 2026HLA

Discovery of the Novel HLA‐B*40:337:02N Allele in a Taiwanese Individual

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The aim is to identify and characterize a novel allele of the HLA-B gene in a specific individual.
Analysis of nucleotide sequences
Identification of substitutions
Characterization of allele variations
Discovery of HLA-B*40:337:02N as a null allele
Documented nucleotide substitution at codon 97

Identifies a novel null allele, HLA-B*40:337:02N, in an individual from Taiwan, suggesting new genetic variations in the population.

A nucleotide substitution in codon 97 of HLA-B*40:337:01N results in a novel null allele, HLA-B*40:337:02N.

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Yang et al. (2026) studied this question.

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Identifies a novel null allele, HLA-B*40:337:02N, in an individual from Taiwan, suggesting new genetic variations in the population.

A nucleotide substitution in codon 97 of HLA-B*40:337:01N results in a novel null allele, HLA-B*40:337:02N.