February 26, 2024Journal of Veterinary Emergency and Critical Care

Successful treatment of a severe 5‐hydroxytrytophan intoxication using carbon hemoperfusion, hemodiafiltration, and mechanical ventilation in a dog

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Authors

JHJiwoong HerNorth Carolina State University DGDaniel S. GordonUniversity of Colorado Boulder ARAlexandra H. RiggsThe Ohio State University

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Implication

Case report demonstrates successful reversal of severe 5-hydroxytryptophan toxicosis in a dog, highlighting combined extracorporeal therapy to reduce mortality from massive overdoses.

Key Points

Complete clinical recovery from severe 5-hydroxytryptophan toxicosis was achieved with carbon hemoperfusion, hemodiafiltration, and mechanical ventilation in a dog.
Extraction ratios reached 93.6%–98.9% across the carbon hemoperfusion filter, and the patient was successfully weaned from mechanical ventilation within 8 hours.
Extracorporeal carbon hemoperfusion coupled with hemodiafiltration processed 46.5 L of blood, highlighting an effective intervention for severe serotonin syndrome.

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Her et al. (2024) studied this question.

synapsesocial.com/papers/68e779e4b6db6435876ee490 https://doi.org/10.1111/vec.13368

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Implication

Case report demonstrates successful reversal of severe 5-hydroxytryptophan toxicosis in a dog, highlighting combined extracorporeal therapy to reduce mortality from massive overdoses.

Successful treatment of a severe 5‐hydroxytrytophan intoxication using carbon hemoperfusion, hemodiafiltration, and mechanical ventilation in a dog

Discussion

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Implication

Key Points

Cite This Study

Successful treatment of a severe 5‐hydroxytrytophan intoxication using carbon hemoperfusion, hemodiafiltration, and mechanical ventilation in a dog

Discussion

Member takes

Implication

Key Points

Cite This Study

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