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Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbi-mortality in all ages. In this context, non-obese PWS patients showed low frequency of metabolic syndrome (MetS), while a high prevalence of hypertension was observed in obese PWS and obese controls. The aim of this report was to estimate the occurrence of high blood pressure and its components in a large group of PWS adults. An association of this syndrome with elevated cardiovascular morbi-mortality was observed, but the underlying mechanisms are not fully known.
Ziani et al. (Sat,) studied this question.