Key result
Endothelial KLF4 overexpression protects against experimental HFpEF, improving exercise tolerance and cardiac parameters.
Population
Experimental HFpEF models (mice)
Design
Preclinical
Authors
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Endothelial KLF4 plays a critical protective role in the pathophysiology of HFpEF, identifying it as a potential mechanistic target for future therapies.
Endothelial KLF4 plays a critical protective role in the pathophysiology of HFpEF, identifying it as a potential mechanistic target for future therapies.
Das et al. (2025) studied Heart failure with preserved ejection fraction (HFpEF). Endothelial KLF4 overexpression vs. Endothelial loss of KLF4 / Control was evaluated on Development of experimental HFpEF (echocardiographic parameters, coronary flow reserve, exercise tolerance, cardiac steatosis and fibrosis). Endothelial overexpression of KLF4 protected mice from experimental HFpEF by improving echocardiographic parameters and exercise tolerance, whereas loss of KLF4 exacerbated the condition.
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