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October 10, 2025Circulation Research

Abstract Wed089: Deciphering transcriptome and cell-cell communication signature in heart failure with preserved ejection fraction at single cell resolution

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Authors

JHJijun HuangCZChaoqun ZhuDPDiana Pham

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Overview

Analysis reveals altered transcriptome and cell-cell communication in heart failure, suggesting insulin's role.

Key Points

  • Altered transcriptional profiles indicate cellular communication changes in heart failure with preserved ejection fraction.
  • Diastolic dysfunction was exacerbated in insulin receptor knockout models fed a high fat diet.
  • Single nuclei RNA sequencing elucidated significant transcriptional changes across cell types in heart failure.
  • Insulin signaling appears integral to organ-wide communication mechanisms in the progression of heart failure.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68e861a57ef2f04ca37e47cbhttps://doi.org/10.1161/res.137.suppl_1.wed089
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract Wed091: Biomechanical and Transcriptomic Remodeling of the Heart in Heart Failure with Preserved Ejection Fraction2025
  2. 2Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction2024 · 52 citations
  3. 3Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in murine heart failure with preserved ejection fraction2023 · 2 citations
  4. 4Circulating Immune Cell Signature Analysis in HFpEF Across Species2025 · 7 citations
  5. 5Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction2024 · 16 citations