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October 9, 2025International Immunology

Role of group 2 innate lymphoid cells in intranasal sensitization-induced allergic rhinitis in mice

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Authors

YKYukinori KatoTTTetsuji TakabayashiASAnna Shimizu

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Overview

This research demonstrates how ILC2s contribute to allergic rhinitis in mice following intranasal sensitization, indicating their role in type 2 inflammation.

Key Points

  • Allergic rhinitis onset was significantly correlated with ILC2 activation during long-term intranasal sensitization in mice.
  • Short-term sensitization caused eosinophilic inflammation and a calcium influx response, but did not induce ILC2 proliferation.
  • Assessment of sneezing, serum-specific IgE, and eosinophil infiltration highlighted distinct immune responses in allergic rhinitis.
  • Findings suggest a critical role of the protease/IL-33/ILC2/IL-5 axis in initiating allergic inflammation and rhinitis.

Cite This Study

Kato et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fc75https://doi.org/10.1093/intimm/dxaf060
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Also Consider

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  5. 5The Expanding Role of <scp>ILC2s</scp> in Allergic Airways Disease2025 · 7 citations