February 21, 2024Open Access

Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization

JSJohanna L. SmithMayo Clinic in Florida CTCatherine TcheandjieuGladstone Institutes ODOzan DikilitasWinnMed

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Abstract

Predictive performance of polygenic risk scores (PRS) varies across populations. To facilitate equitable clinical use, we developed PRS for coronary heart disease (CHD; PRS

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Smith et al. (Wed,) studied this question.

synapsesocial.com/papers/68e78329b6db6435876f5ed9 https://doi.org/https://doi.org/10.1161/circgen.123.004272

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