Key result
New translational platform profiles murine diastolic function by linking in-vivo echo with ex-vivo mechanics and energetics.
Population
Male, 8-10-week-old wild-type mice
Design
Preclinical
Authors
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A platform integrating in-vivo echocardiography with ex-vivo mechanical and metabolic assays was successfully established to study diastolic function in mice.
A platform integrating in-vivo echocardiography with ex-vivo mechanical and metabolic assays was successfully established to study diastolic function in mice.
Mukherjee et al. (2025) studied Left ventricular diastolic dysfunction. Integrated mechano-metabolic measures was evaluated on Mechano-metabolic indices of diastolic function (stiffness, E/e' ratio, ATP levels). An integrated platform combining in-vivo echocardiography with ex-vivo mechanical testing and metabolic assays was established in mice, measuring average basal ATP levels at 1.75 ± 0.58 nmol.
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