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October 12, 2025Regional Anesthesia The Journal of Neural Blockade in Obstetrics Surgery & Pain Control

Epidural Morphine Anesthesia for Abdominal Aortic Surgery—Pharmacokinetics

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Authors

TITraian I. Ionescu RDR. H. Drost EWE K Winckers

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Implication

Observational analysis recorded morphine pharmacokinetics in plasma and CSF during abdominal aortic surgery, suggesting varying influences from the procedure.

Key Points

Peak plasma concentrations of morphine were observed at 8.0 ± 2.6 minutes after epidural injection.
Free morphine was undetected in plasma after 360 minutes, while varying fractions persisted in CSF.
Initial plasma and CSF concentrations of morphine appeared 2 minutes post-injection, indicating rapid onset.
Factors contributing to the variability in plasma and CSF pharmacokinetics were discussed, highlighting procedural influence.

Cite This Study

Ionescu et al. (1989) studied this question.

synapsesocial.com/papers/68eb6f7ceea689731b3006cd https://doi.org/10.1136/rapm-00115550-198914030-00003

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Implication

Observational analysis recorded morphine pharmacokinetics in plasma and CSF during abdominal aortic surgery, suggesting varying influences from the procedure.

Epidural Morphine Anesthesia for Abdominal Aortic Surgery—Pharmacokinetics

Discussion

Member takes

Implication

Key Points

Cite This Study

Epidural Morphine Anesthesia for Abdominal Aortic Surgery—Pharmacokinetics

Discussion

Member takes

Implication

Key Points

Cite This Study

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