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October 12, 2025Antimicrobial Agents and ChemotherapyOpen Access

In vitro evolution of durlobactam resistance in NDM-producing Escherichia coli due to a single mutation in mrdA encoding penicillin-binding protein 2

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Authors

CMChristi L. McElhenyEBEugene C. ButcherAKAkito Kawai

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Overview

Experimental analysis reveals a significant rise in resistance levels in E. coli, suggesting mutations in mrdA can impact drug efficacy.

Key Points

  • Resistance to durlobactam was found to increase significantly in the mutant strain.
  • The minimum inhibitory concentration rose to 2 µg/mL, indicating a sharp increase from baseline levels.
  • A point mutation in the mrdA gene was identified as the primary driver of this resistance.
  • These findings highlight the challenges faced in combating antibiotic resistance in bacterial pathogens.

Cite This Study

McElheny et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdaca2https://doi.org/10.1128/aac.01014-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Growing Threat of NDM-Producing <i>E. Coli</i> With Penicillin-Binding Potein 3 Mutations in the United States—Is There a Potential Role for Durlobactam?2024 · 9 citations
  2. 2Durlobactam, a Diazabicyclooctane β-Lactamase Inhibitor, Inhibits BlaC and Peptidoglycan Transpeptidases of <i>Mycobacterium tuberculosis</i>2024 · 2 citations
  3. 3Loss and resurgence of multi-drug-resistance during laboratory evolution of a carbapenem-resistant isolate of Escherichia coli2026
  4. 4A 4-methyl-substituted durlobactam analogue as a potential class-D oxacillinase inhibitor in Acinetobacter baumannii—an in silico study2026 · 1 citations
  5. 5Optimizing target inactivation to treat multidrug-resistant <i>Escherichia coli</i> with NDM and PBP3 mutations: “going the extra mile”2026 · 6 citations