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October 12, 2025Archiv der Pharmazie

Chemometrics‐Assisted Spectrophotometric Methods for Determination of Methocarbamol and Paracetamol Along With Two Related Impurities: An Environmental Sustainability Assessment

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Authors

KKKhadiga M. KelaniCairo UniversityHEHebatallah M. EssamAMA. MohamedAlbert Einstein College of Medicine

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Overview

Multivariate models assess methocarbamol and paracetamol, revealing their related impurities and sustainability implications.

Key Points

  • The methods provide accurate determination of methocarbamol, paracetamol, and their impurities.
  • Calibration models based on principal component regression and partial least squares demonstrated high reliability.
  • Techniques scored 67.70% on the NQS index, indicating strong sustainability alignment.
  • Environmental metrics evaluated show these methods have superior performance in terms of greenness and effectiveness.

Cite This Study

Kelani et al. (2025) studied this question.

synapsesocial.com/papers/68ec1be02b8fa9b2b78ad2cfhttps://doi.org/10.1002/ardp.70114
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Validated Spectrophotometric Approach for the Concurrent Estimation of Paracetamol and Methocarbamol in Combined Tablet Formulations with Practicality and Greenness Assessment2026
  2. 2Simultaneous spectroscopic analysis of methocarbamol with its impurity guaifenesin: assessment of greenness, blueness and whiteness applying different sustainability tools2026
  3. 3Evolving Analytical Methods for the Quantification of Methocarbamol: A Critical Review2026 · 2 citations
  4. 4Eco‐Conscious RP‐HPLC Method for Concurrent Quantification of Assay and Dissolution Testing of Methocarbamol and Diclofenac Potassium in Tablet Formulations2026
  5. 5A Green High‐Performance Liquid Chromatographic Approach for the Simultaneous Determination of Paracetamol and Aspirin Alongside Their Toxic and Major Impurities2026 · 1 citations