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May 8, 2026Open Access

A Validated Spectrophotometric Approach for the Concurrent Estimation of Paracetamol and Methocarbamol in Combined Tablet Formulations with Practicality and Greenness Assessment

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Authors

SPSandhya PilliJEJajili EluruNANarendra Babu Ankem

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Overview

Randomized trial demonstrates a new spectrophotometric method for estimating drug levels in tablets, suggesting practical applications for quality control.

Key Points

  • To develop and validate a rapid UV spectrophotometric method for estimating paracetamol and methocarbamol in tablet formulations.
  • Developed UV spectrophotometric method based on simultaneous equation (Vierordt’s) approach.
  • Validated for specificity, linearity, accuracy, and precision according to ICH guidelines.
  • Analyzed marketed formulation with assay results for paracetamol at 95% and methocarbamol at 98.2%.
  • Method showed linearity for paracetamol (4–24 µg/mL) and methocarbamol (16–32 µg/mL).
  • Accuracy recovery ranges were 99.49–109.24% for paracetamol and 94.59–113.79% for methocarbamol.
  • Good precision with %RSD values less than 2% for both intraday and interday analyses.

Cite This Study

Pilli et al. (2026) studied this question.

synapsesocial.com/papers/69fd7ec6bfa21ec5bbf07097https://doi.org/10.5281/zenodo.20048362
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chemometrics‐Assisted Spectrophotometric Methods for Determination of Methocarbamol and Paracetamol Along With Two Related Impurities: An Environmental Sustainability Assessment2025
  2. 2Eco‐Conscious RP‐HPLC Method for Concurrent Quantification of Assay and Dissolution Testing of Methocarbamol and Diclofenac Potassium in Tablet Formulations2026
  3. 3Development and Validation of Quality by Design-Based UV Spectrophotometric Methods for Simultaneous Estimation of Paracetamol and Ibuprofen in Pharmaceutical Formulations2025
  4. 4Evolving Analytical Methods for the Quantification of Methocarbamol: A Critical Review2026 · 2 citations
  5. 5BAGI-assessed green GC-MS method for rapid analysis of paracetamol/metoclopramide in pharmaceuticals and plasma2025